Sharks centre Josh Dugan has been ruled out of the team to face the Panthers tomorrow night with a shoulder injury.
Dugan's place in the Sharks side is likely to be taken by young outside back Jesse Ramien.
Dugan trained on Tuesday, however after today's Captain's Run it was felt he wasn't 100 per cent fit and was therefore withdrawn from the team by club medical staff, the decision coming late this afternoon.
The Sharks 19-man squad will become official later tonight, 24 hours before the scheduled kick off to tomorrow's game.
The Sharks v Panthers clash is set down for Allianz Stadium on Friday night, with kick-off at 7.50pm.