The Sharks now have an entire NRL team, 13 players from their top squad, sidelined for the match with the Dragons with Luke Lewis and John Morris both set to miss the match.
Lewis has succumbed to a knee injury, while Morris has a neck problem, with the pair withdrawing late in the week.
In their place the experienced Isaac De Gois comes into the starting team at hooker, with youngster Micheal Lichaa onto the interchange bench.
In the backrow, coach Peter Sharp has called upon Tupou Sopoaga to take Lewis's place.
The match will also see the debut of five eighth Fa'amanu Brown and winger Jacob Gagan for the Sharks, with the pair set for an interesting night marking Benji Marshall, Josh Dugan and Jason Nightingale.
Kickoff is scheduled for 7.30pm at WIN Stadium.